Case Studies

A Structured Approach to Whole Process Review

Read how Britest has enabled biotechnology pioneers Biogen to conduct a structured review of manufacturing operations with an end-to-end view of the entire manufacturing process in order to guarantee product quality and robustness.

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Process DesignTechnical Facilitation


Supporting Complex Decision Making in Route Selection

For complex, multiple step separations there are often many possible routes to the end product. This is exacerbated if several products are to be manufactured from a single feed-stream. Faced with this challenge, Johnson Matthey turned to Britest tools and methodologies to find the optimal process route for separation of platinum group metals.

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Decision MakingProcess Design


Process Options - Balancing Development Risk and Commercial Opportunity

In process development several potentially viable options may be on the table, each with its own complicated risk - reward relationship. This case study from Johnson Matthey shows how a process development team used Britest to make  progress in deciding between several process options with disparate project/developmental risks and potential commercial impact.without sacrificing appropriate rigour in their decision making process.

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Decision MakingProcess Design


Gap Analysis at the Start of New Process Development

Britest facilitation of a process for open dialogue between manufacturers, equipment providers and key stakeholders provided the framework for dialogue needed for Johnson Matthey to engage in a collaborative research and development programme to develop an improvement approach to recycling Platinum Group Metals. Beneficial outcomes were minimisation of research risk, identification of uncertainty, and stakeholder buy-in.

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Process DesignTechnical Facilitation


Supporting scale-up in an innovative start-up business

Conductive Organics, is a University of Strathclyde spin-out company, working to produce the next generation of conductive organic materials for use in emerging technologies such as Organic Light Emitting Diodes (OLED's). A Britest study enabled Conductive Organics to address the challenge of scaling-up the synthesis of the key organic compound at the heart of their innovative formulations, and to gather underpinning information to support their emerging business plan.

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Process DesignScale-upSpeciality Chemicals


Improving Food Operations Training

Stu Brew is Europe’s first student run microbrewery, helping students gain hands on experience at running a business, operating equipment and researching sustainability improvements for the brewing process. This case study describes how Britest tools have been used by Newcastle University to support operation of the microbrewery, and in particular to help train student operators to enhance process understanding.

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Britest coordinating collaborations

Participation in strategic initiatives such as the EU H2020:SPIRE Public-Private-Partnership opens up powerful influencing routes and further opportunities, but it takes excellent project management skills to pull the complex elements of a collaborative project together into a coherent whole. This case study describes how Britest brought together a consortium of ten partners to successfully bid for and deliver a two-year project collating views from EU process industry sectors, public sector, academics and sustainability experts to positively influence future approaches to sustainability evaluation across the EU.

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Horizon ScanningPartneringSustainability


Troubleshooting Reaction Issues in Additives Manufacture

An example of how a Britest study enabled one of the world's leading formulators, manufacturers and marketers of fuel and lubricant additives to gain a fundamental understanding of the influence of raw material composition and process conditions on the properties of a free-radically produced polymer which wasn't always hitting the mark. Having identified an issue in a critical raw material, Infineum were able to agree a new monomer specification with their supplier and save £350k a year.

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Problem SolvingSpeciality Chemicals


Use of Britest to aid Communication and Problem Solving

Read how the use of the Britest tools and approach encouraged chemists and engineers in a large manufacturing organisation to address a problem in pressure filtration which had been dragging on for three years - saving the business £500K a year. 

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PharmaProblem SolvingTechnical Facilitation


Rapid optimisation of a new process in Pharmaceutical API manufacture

Read how Britest successfully provided the structured approach needed by a process development centre within a large multi-national pharmaceutical business to optimise a new process in a very short time period.

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PharmaProcess Design


Collaboration, customer focus and value creation - delivering JM's core values

Johnson Matthey Emission Control Technologies develops and manufactures coated catalyst systems for automotive applications. This case study exemplifies a typical study where Britest tools act as a focus to bring together different disciplines and business locations in collaborative programmes allowing JM to deliver its core values.

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Process DesignSpeciality Chemicals


Britest Methodology Implementation in Specialist Additive Manufacturing and Formulation

This case study summarises how Infineum and Britest together developed an approach to effectively embed Britest in the organisation and the value gained.

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Speciality ChemicalsTechnical Facilitation


Britest Improvement Study to Increase Throughput by 50%

This case study describes the elements of a Britest throughput improvement study carried out by a custom synthesis manufacturer to meet an identified customer need to increase process throughput by at least 50% within three years, which was successfully delivered by halving batch times.

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Custom ManufactureProcess Design


Technology Transfer Made Easy in a Contract Manufacturing Organisation

Read how a Britest facilitator was able to help a contract manufacturing organisation who did not know the Britest tools identify a common language for effective technology transfer.

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Custom ManufactureProcess DesignTechnical Facilitation


Challenging ideas on an established manufacturing process

How do you reduce costs and drive value when you've been operating a process for 25 years? This Britest study with a fine chemical company did exactly that by challenging established idea of what was and wasn't optimal in the process chemistry to speed up and simplify the reaction route.

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Custom ManufactureProblem SolvingProcess DesignSpeciality Chemicals


Customer and Supplier Working Together as a Team

An illustration of how two Britest members in a supplier/customer relationship were able to use Britest as a framework for working together to solve a problem with a chemical intermediate product.

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Problem SolvingSpeciality Chemicals


Britest in Drug Product Development

A large pharmaceutical manufacturing Britest member had identified processing issues associated with a micronisation step during late stage development with several new drug candidates intended for inhalation. A multi-disciplinary, cross-site team was put together which used Britest tools to identify key material attributes, equipment and process parameters impacting upon the micronisation unit operation. With the root causes identified the team was able to define a generic workflow and guidance for successful micronisation in the future.

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PharmaProblem Solving