Case Studies - TOOL - Rich Pictures

Overcoming Analytical Sample Preparation Issues to Improve Method Reliability

Analytical scientists at AstraZeneca were able to rapidly and effectively identify and eliminate subtle procedural variations in a test method being used to make product quality decisions with significant cost implications for any batch wrongly rejected. Britest tools were used to visualise the sample preparation regime in detail, breaking it down to identify potential sources of variation, and prioritise these for further investigation in a factorial experimental design. Re-wording the test method restored the method to control, saving $10-50k per out of specification result prevented.

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- PROBLEM SOLVINGAnalytical ChemistryPharmaTOOL - Rich Pictures




Improving Access to Organisational Knowledge: A Visual Understanding of a Key Unit Operation

A large company in the pharmaceuticals sector has been able to transform the availability and hence use of existing information and existing work on the commonly used isolation technique of pressure filtration. Britest Rich Pictures and Cartoons provided an elegant format to portray and summarise current information and understanding, and by digitising these into a dedicated internal site, AstraZeneca were able to produce an easy to use guide to pressure filtration development.

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- EFFECTIVE COLLABORATION- KNOWLEDGE SHARING- OPERATIONAL EXCELLENCESkills DevelopmentTOOL - Rich Pictures




Optimising Plant Changeover / Cleaning Processes

A Britest methodology to support the optimisation of changeover/cleaning processes was used to help FUJIFILM Imaging Colorants address capacity constraints. Improvements to significantly time-consuming steps, and opportunities for improvements to existing CIP equipment were identified, along with a more ambitious opportunity to reduce the cleaning cycle time from 2-3 days to 12 hours through targeted use of a key cleaning solvent.

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- EFFECTIVE COLLABORATION- TECHNICAL FACILITATIONProcess EfficiencyProcess ImprovementSpeciality ChemicalsTOOL - Process Information Summary MapTOOL - Rich Pictures




Improving Food Operations Training

Stu Brew is Europe’s first student run microbrewery, helping students gain hands on experience at running a business, operating equipment and researching sustainability improvements for the brewing process. This case study describes how Britest tools have been used by Newcastle University to support operation of the microbrewery, and in particular to help train student operators to enhance process understanding.

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- KNOWLEDGE SHARING- OPERATIONAL EXCELLENCEBiotechnologyFoodTOOL - Process Definition DiagramTOOL - Rich PicturesTraining




Use of Britest to aid Communication and Problem Solving

Read how the use of the Britest tools and approach encouraged chemists and engineers in a large manufacturing organisation to address a problem in pressure filtration which had been dragging on for three years - saving the business £500K a year. 

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- EFFECTIVE COLLABORATION- PROBLEM SOLVING- TECHNICAL FACILITATIONPharmaTOOL - Process Definition DiagramTOOL - Rich Pictures




Problem Solving through Process Understanding - Particle Coating for Controlled Release

Read how a Britest problem solving study rapidly enabled a major pharmaceutical manufacturer to get a controlled release drug capsules product back to target release profile after transferring the process to new manufacturing equipment.

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- PROBLEM SOLVINGPharmaTOOL - Process Definition DiagramTOOL - Rich Pictures







Britest Improvement Study to Increase Throughput by 50%

This case study describes the elements of a Britest throughput improvement study carried out by a custom synthesis manufacturer to meet an identified customer need to increase process throughput by at least 50% within three years, which was successfully delivered by halving batch times.

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- OPERATIONAL EXCELLENCECustom ManufactureProcess DesignProcess ImprovementTOOL - Driving Force AnalysisTOOL - Initial Screening AnalysisTOOL - Process Definition DiagramTOOL - Process Information Summary MapTOOL - Rich PicturesTOOL - Transformation Map




Britest in Drug Product Development

A large pharmaceutical manufacturing Britest member had identified processing issues associated with a micronisation step during late stage development with several new drug candidates intended for inhalation. A multi-disciplinary, cross-site team was put together which used Britest tools to identify key material attributes, equipment and process parameters impacting upon the micronisation unit operation. With the root causes identified the team was able to define a generic workflow and guidance for successful micronisation in the future.

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- PROBLEM SOLVINGPharmaTOOL - Driving Force AnalysisTOOL - Rich Pictures