Case Studies - Process Efficiency

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Efficient Analytical Validation Using Britest Visualisations As Protocols

Protocols for Liquid Chromatography method validations under GMP often require complex dilution schemes with many opportunities for errors in execution. This necessitates inefficient extra checks, and duplication of work (further consuming valuable API). Presenting the dilution schemes visually using a Britest ‘Rich-PrISM’ has made the dilution schemes far easier for analysts to follow. The result is substantially reduced lead time and resource consumption, and all protocols executed 'right first time'.

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- KNOWLEDGE SHARING- OPERATIONAL EXCELLENCEAnalytical ChemistryBest PracticeProcess EfficiencyProcess ImprovementTOOL - Process Information Summary MapTOOL - Rich Pictures




Optimising Plant Changeover / Cleaning Processes

A Britest methodology to support the optimisation of changeover/cleaning processes was used to help FUJIFILM Imaging Colorants address capacity constraints. Improvements to significantly time-consuming steps, and opportunities for improvements to existing CIP equipment were identified, along with a more ambitious opportunity to reduce the cleaning cycle time from 2-3 days to 12 hours through targeted use of a key cleaning solvent.

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- EFFECTIVE COLLABORATION- TECHNICAL FACILITATIONProcess EfficiencyProcess ImprovementSpeciality ChemicalsTOOL - Process Information Summary MapTOOL - Rich Pictures




Increasing Production of a Speciality Chemical by 50% to meet demand

This case study describes how a Britest study enabled an internal cross-functional team at Robinson Brothers Limited to rapidly identify and implement process changes designed to improve efficiency and up time, making it possible to support extra sales of ~£1M p.a.

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- WHOLE PROCESS UNDERSTANDINGProcess DesignProcess EfficiencyProcess ImprovementTOOL - Process Information Summary Map